FIGURE 4.

Gross observation and shape analysis of the constructs with different plane shape during different stages demonstrated that all groups maintain the original size after in vitro and in vivo incubation (A _A-F ). Furthermore, shape evaluation of ear-shaped construct with different support modes. After 2 weeks of in vitro culture, the auricular constructs are implanted in nude mice separately, including PCL inner support group, titanium outer support group, and without any support group indicated that all groups maintain their original auricular shape with detailed structures and high shape similarity of 90.34% and 86.15%, respectively. However, the specimen without any support almost loses its original shape and shrinks obviously with a shape similarity of 28.53% (B). Reproduce with permission from (Yin et al., 2020) under Right Link share.