FIG. 4.

The effect of paromomycin treatment  (0 [○], 500 [◂], 1,000 [■], or 2,000 [•] mg/kg/day) on oocyst shedding was assessed in mice that had been infected with 100 oocysts. Treatment was begun on day 8 of infection. By day 11 and thereafter, there was a dose-related decrease in oocyst shedding in all groups receiving paromycin treatment. This relationship was highly significant on all days  (F = 235.35, P < 0.001, regression analysis). On day 18, there were no mice in the untreated group because all  (7 of 7) had died, whereas in the treated groups only 1 of 21 had died  (by Fisher’s exact test, P < 0.001 for differences in survival). CI, confidence interval.