FIG. 5.

The weights of uninfected GKO mice  (□) and of GKO mice infected with 100 oocysts on day 0 and treated with paromomycin  (0 [○], 500 [◂], 1,000 [■], or 2,000 [•] mg/kg/day) on day 8 and thereafter are displayed. Four days after infection, there were no differences in weight among the treatment groups. In contrast, by 11 days after inoculation and thereafter, there was a highly significant difference in the weights of the uninfected control mice and the untreated  (placebo) control group  (means ± standard deviations, 21.31 ± 0.38 g and 14.25 ± 0.57 g, respectively; P < 0.001). The infected, untreated mice weighed only 67% as much as the uninfected mice. Paromomycin treatment very significantly blunted this decrease in weight in a dose-dependent fashion  (F = 25.881, P < 0.001). CI, confidence interval.