Table 2.

Univariate and multivariate Cox regression analysis dependent on blast count (top) and TP53 state (bottom)

	Univariate		Multivariate
	P value	HR	P value	HR
Total cohort
TP53 single hit	.043	1.4	.003	1.6
TP53 double hit	< .001	4.9	< .001	3.9
Blast count (<5%, ≥5%)	< .001	1.9	< .001	1.8
Complex karyotype	< .001	3.2	.047	1.3
MDS with <5% blasts
TP53 single hit	.018	1.7	.021	1.7
TP53 double hit	< .001	4.9	.041	2.2
Complex karyotype	< .001	7.0	< .001	5.2
MDS with ≥5% but <10% blasts
TP53 single hit	.028	2.2	.026	2.3
TP53 double hit	< .001	12.1	< .001	9.2
Complex karyotype	< .001	4.1	ns	—
MDS with ≥10% but <20% blasts
TP53 single hit	n.s.	—	—	—
TP53 double hit	< .001	5.6	.004	4.6
Complex karyotype	< .001	3.2	ns	—
AML
TP53 single hit	.039	1.5	.044	1.6
TP53 double hit	< .001	4.4	< .001	4.2
Complex karyotype	< .001	2.6	n.s.	—

	Univariate		Multivariate
	P value	HR	P value	HR
Without TP53 alteration
Blast count (<5%, ≥5%)	< .001	1.8	< .001	1.8
Complex karyotype	.038	1.6	ns	—
TP53 single hit
Blast count (<5%, ≥5%)	.007	2.2	.013	2.2
Complex karyotype	.035	1.5	n.s.	—
TP53 double hit
Blast count (<5%, ≥5%)	.008	2.9	.008	2.9
Complex karyotype	ns	—	—	—

ns, not significant.