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. 2023 Sep 22;20:67. doi: 10.1186/s12987-023-00468-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Representative brain slices showing BBBo for the combined L-PEFs + Doxo group and the Doxo only group immediately post treatment. A representative contrast-enhanced T1-MRI slice depicting the enhancing tumor (arrow) is shown on the left, and 2 slices showing pixels included in the area over the threshold (AOT), representing BBBo near the tumor and in further cortical areas, are shown on the right. (A) Combined L-PEFs + Doxo group (N = 5). (B) Doxo only group (N = 5)