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. 2023 Jul 18;208(6):709–725. doi: 10.1164/rccm.202210-2015OC

Figure 2.

Figure 2.

Single-nucleus transcriptome atlas of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) and control human lungs. (A) UMAP embedding of snRNA-seq of nuclei (n = 65,809) from ACDMPV (n = 5), preterm neonates (n = 3; 1–4 d of age and 29–31 wk of gestational age), and control lungs (n = 3; 3 yr old). (B) Dot plot of average expression amounts and expression percentage of FOXF1 RNA in each cell type in each lung. Expression with percentage ⩾2% is shown. (C) Dot plot of RNA expression of marker genes in single-nucleus RNA–identified cell types in A. Gene expression with percentage ⩾5% is shown. ABCA3 = ATP binding cassette subfamily A member 3; ACKR1 = atypical chemokine receptor 1; AEC = arterial endothelial cell; AF1 = alveolar fibroblast 1; AF2 = alveolar fibroblast 2; AGER = advanced glycosylation end-product specific receptor; AM = alveolar macrophage; ASCL1 = achaete-scute family BHLH transcription factor 1; ASMC = airway smooth muscle cell; AT1 = alveolar type 1 cell; AT2 = alveolar type 2 cell; CAP1 = capillary 1 cell; CAP2 = capillary 2 cell; CCL21 = C-C motif chemokine ligand 21; CCR7 = C-C motif chemokine receptor 7; CD96 = cluster of differentiation 96; cDC1 = classical dendritic cell subset 1; cDC2 = classical dendritic cell subset 2; CLDN4 = claudin 4; CLEC = C-type lectin domain containing; COL15A1 = collagen type XV α 1 chain; COL2A1 = collagen type II α 1 chain; DC = dendritic cell; DKK2 = Dickkopf WNT signaling pathway inhibitor 2; F13A1 = coagulation factor XIII A chain; FCGR3A = Fc gamma receptor IIIa; FCN = ficolin; FOXF1 = forkhead box F1; FOXJ1 = forkhead box J1; GNLY = granulysin; HBB = hemoglobin subunit β; HPGD = 15-hydroxyprostaglandin dehydrogenase; IM = interstitial macrophage; iMON = inflammatory monocyte; ITGBL1 = integrin subunit β like 1; LAMC3 = laminin subunit gamma 3; LEC = lymphatic endothelial cell; LGR6 = leucine rich repeat–containing G 55protein–coupled receptor 6; maDC = mature dendritic cell subset; MARCO = macrophage receptor with collagenous structure; MFAP5 = microfibril associated protein 5; MS4 = membrane spanning 4-domains; MyoFB = myofibroblast; MZB1 = marginal zone B and B1 cell-specific protein; NK = natural killer; NTRK3 = neurotrophic receptor tyrosine kinase 3; pDC = plasmacytoid dendritic cell; pMON = patrolling monocyte; PNEC = pulmonary neuroendocrine cell; RASC = respiratory airway secretory cell; SCGB3A = secretoglobin family 3A; snRNA-seq = single-nucleus RNA sequencing; SVEC = systemic vascular endothelial cell; TCF21 = transcription factor 21; TP53 = tumor protein P53; UMAP = uniform manifold approximation and projection; VEC = venous endothelial cell; VSMC = vascular smooth muscle cell.