Table 1.

Percentage of pediatric acute liver failure attributed to inherited metabolic disease.

Age	Metabolic liver disease (MLD)	MLD mortality	Indeterminate	Ref
<90 d	28/148 (19%)	29%	56/148 (38%)	[8]
<120 d	28/78 (36%)	8/28 (29%)	5/78 (6%)	[9]
Infants (<12 m)	34/80 (43%)	14/34 (41%)	13/80 (16%)	[10]
< 24 m (median 1.3 m)	18/34 (53%)	8/18 (44%)	-	[11]
<2 y	12/28 (43%)	3/12 (25%)	5/28 (18%)	[12]
<3 y (median 12.5 m)	10/30 (33%)	7/10 (70%)	3/30 (10%)	[13]
<18 y	14/109 (13%)	8/14 (57%)	16/109 (15%)	[14]
0–18 y	36/348 (10%)	8/36 (22%)	169/348 (49%)	[15]
0–17 y	15/97 (15%)	11/17 (65%)	-	[16]
Neonatal (<1 m)	3/17 (18%)*	-
Infants (1–12 m)	7/22 (32%)
Early childhood (1–5 y)	3/33 (14%)
Late childhood (5–17 y)	2/36 (6%)**
0–18 y	25/215 (12%)	-	68/215 (32%)	[17]
Neonatal (<28 d)	5/42 (12%)		2/42 (5%)
Infants (29 d-1 y)	3/23 (13%)		8/23 (35%)
Child (1–12 y)	12/95 (13%)		41/95 (43%)
Adolescent (12–18 y)	5/55 (9%)		17/55 (31%)

^*excluding neonatal hemochromatosis;

^**both Wilson disease.