Extended Data Figure 1. Z2075279358 increased the ion flux rate in a bronchial epithelial cell line derived from a patient homozygous for ΔF508 (CFBE41o⁻ cells expressing ΔF508-CFTR and the fluorescent protein eYFP-H148Q/I152L/F46L⁵⁹).

Cells were treated with 20 μM forskolin +/− 1 μM test compound. The relative potentiation was calculated as the ratio of flux rates with and without compound. Data points represent a single measurement for each test compound. For ivacaftor and GLPG1837 data represent means and SEs for 9 or 2 measurements, respectively.