Extended Data Table 1.
Potentiating activities of the 13 CFTR primary hits.
| ID | 2D structure by NMR | Purity (%) | Fold of stimulation (mean ± SEM) |
|---|---|---|---|
| Z2075279358 |
|
99.6 | 2.38 ± 0.24 (n=3) |
| Z2194302854 |
|
98.8 | 1.39 ± 0.08 (n=3) |
| Z1343848401 |
|
99.7 | 1.37 ± 0.08 (n=6) |
| Z2776419998 |
|
99.1 | 1.36 ± 0.08 (n=3) |
| Z1224795288 |
|
97.7 | 1.34 ± 0.08 (n=3) |
| Z19702639 |
|
91.2 | 1.32 ± 0.04 (n=4) |
| Z1096199008 |
|
97 | 1.30 ± 0.04 (n=4) |
| Z873519648 |
|
>99 | 1.27 ± 0.11 (n=3) |
| Z1783799713 |
|
97.8 | 1.25 ± 0.04 (n=4) |
| Z899051432 |
|
>99 | 1.24 ± 0.04 (n=6) |
| Z1262422554 |
|
>99 | 1.17 ± 0.03 (n=5) |
| Z2171315755 |
|
95 | 1.17 ± 0.09 (n=3) |
| Z995908944 |
|
>99 | 1.15 ± 0.03 (n=4) |