a, Normative growth curve and growth rate of global system segregation. The peak occurred in the third decade of life (25.7 years, 95% bootstrap confidence interval 24.8-26.8). The gray shaded areas represent the 95% confidence interval, which was estimated by bootstrapping 1,000 times. b-c, Normative growth curves and growth rate of system segregation for each network. The median (50th) centile is represented by a solid line, while the 5th, 25th, 75th, and 95th centiles are indicated by dotted lines. The key inflection points are marked in blue font. d, Growth rate of system-specific segregation visualized in the cortex, with black lines depicting system boundaries. The values of each system are mapped and visualized on the HCP fs_LR_32k surface. VIS, visual; SM, somatomotor; DA, dorsal attention; VA, ventral attention; LIM, limbic; FP, frontoparietal; DM, default mode. wk, week; yr, year.