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[Preprint]. 2023 Nov 6:2023.09.12.557258. Originally published 2023 Sep 12. [Version 2] doi: 10.1101/2023.09.12.557258

Figure 5. ERK inhibitors differentially cluster with VTX11e/BVD523 or GDC0994.

Figure 5.

Effects of inhibitors on HDX were quantified by a difference AUC measurement, which calculates dAUC = Σt(HDXApo- HDXInhibitor)t over all time points. (A) Plot comparing dAUC for the DFG motif (peptide 161–168) vs P+1 segment (peptide 191–198) reveals 13 inhibitors clustered with VTX11e/BVD523, 3 inhibitors clustered with GDC0994, and one inhibitor with intermediate properties. Labels mark the representative set of inhibitors shown in Fig. 4. (B) dAUC values for each inhibitor.