Table 6.

Urinary isoprostanes at Year 1 and child development at Year 2

Exposure	Outcome	N	25th Percentile	75th Percentile	Outcome, 75th Percentile v. 25th Percentile
					Adjusted
					Predicted Outcome at 25th Percentile	Predicted Outcome at 75th Percentile	Coefficient (95% CI)	P-value
IPF(2a)-III (ng/mg creatinine)	EASQ communication score	551	−0.74	−0.09	0.19	0.21	0.01 (−0.07, 0.1)	0.79
	EASQ gross motor score	546	−0.73	−0.09	0.32	0.24	−0.08 (−0.18, 0.01)	0.08
	EASQ personal social score	551	−0.73	−0.09	0.42	0.41	0 (−0.12, 0.11)	0.97
	Combined EASQ score	550	−0.73	−0.09	0.23	0.21	−0.01 (−0.1, 0.08)	0.8
	CDI expressive language score	558	−0.74	−0.09	0	0.05	0.04 (−0.04, 0.13)	0.34
	CDI comprehension score	554	−0.73	−0.09	0.07	0.13	0.06 (−0.03, 0.15)	0.21
2,3-dinor-iPF(2a)-III (ng/mg creatinine)	EASQ communication score	551	1.54	1.97	0.21	0.17	−0.04 (−0.15, 0.07)	0.49
	EASQ gross motor score	546	1.54	1.97	0.37	0.29	−0.08 (−0.34, 0.18)	0.55
	EASQ personal social score	551	1.54	1.97	0.42	0.35	−0.07 (−0.22, 0.08)	0.38
	Combined EASQ score	550	1.54	1.97	0.21	0.12	−0.09 (−0.22, 0.05)	0.21
	CDI expressive language score	558	1.54	1.97	0.01	−0.03	−0.04 (−0.18, 0.1)	0.6
	CDI comprehension score	554	1.54	1.97	0.08	0.05	−0.03 (−0.15, 0.09)	0.64
iPF(2a)-VI (ng/mg creatinine)	EASQ communication score	551	2.3	2.87	0.18	0.1	−0.08 (−0.21, 0.04)	0.19
	EASQ gross motor score	546	2.31	2.87	0.33	0.27	−0.07 (−0.17, 0.04)	0.22
	EASQ personal social score	551	2.31	2.87	0.42	0.28	−0.14 (−0.25, −0.03)	0.01
	Combined EASQ score	550	2.3	2.87	0.22	0.12	−0.1 (−0.23, 0.04)	0.15
	CDI expressive language score	558	2.3	2.87	0.01	−0.07	−0.08 (−0.17, 0.02)	0.12
	CDI comprehension score	554	2.31	2.87	0.06	0.05	−0.01 (−0.15, 0.13)	0.91
8,12-iso-iPF(2a)-VI (ng/mg creatinine)	EASQ communication score	551	2.16	2.91	0.2	0.26	0.06 (−0.07, 0.19)	0.36
	EASQ gross motor score	546	2.17	2.91	0.29	0.31	0.02 (−0.09, 0.13)	0.76
	EASQ personal social score	551	2.17	2.91	0.41	0.42	0 (−0.12, 0.12)	0.97
	Combined EASQ score	550	2.17	2.91	0.21	0.25	0.04 (−0.1, 0.17)	0.6
	CDI expressive language score	558	2.17	2.91	0.01	−0.02	−0.03 (−0.22, 0.16)	0.76
	CDI comprehension score	554	2.17	2.91	0.03	0.09	0.05 (−0.13, 0.24)	0.57
Combined urinary oxidative status score	EASQ communication score	551	2.48	3.56	0.19	0.19	−0.01 (−0.11, 0.1)	0.9
	EASQ gross motor score	546	2.49	3.55	0.32	0.27	−0.06 (−0.17, 0.05)	0.31
	EASQ personal social score	551	2.48	3.56	0.42	0.38	−0.04 (−0.16, 0.08)	0.49
	Combined EASQ score	550	2.48	3.55	0.23	0.19	−0.04 (−0.15, 0.08)	0.54
	CDI expressive language score	558	2.47	3.55	0	0.02	0.02 (−0.08, 0.12)	0.72
	CDI comprehension score	554	2.49	3.54	0.05	0.11	0.06 (−0.05, 0.17)	0.28

Analyses adjusted for child age and child sex, and screened the following covariates for potential inclusion (see Appendix 3 for details) -- child birth order, maternal age, maternal height, maternal education, household food insecurity, number of children in the household, number of individuals living in the compound, distance to primary drinking water source, household assets, prior anthropometry, month of assessment, treatment arm, pre-stressor sample collection time, maternal Center for Epidemiologic Studies Depression Scale score, maternal Perceived Stress Scale score, and maternal lifetime cumulative exposure to intimate partner violence. CDI: MacArthur-Bates Communicative Development Inventories; EASQ: Extended Ages and Stages Questionnaire

^*P-value < 0.2 after adjusting for multiple comparisons using the Benjamini-Hochberg procedure