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. 2023 Sep 7;14:1243523. doi: 10.3389/fmicb.2023.1243523

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Copyright © 2023 Davis, Payne, Olguin, Sanders, Clements, Stefan, Williams, Hooper, Huggins, Mucker and Ricks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening of MAbs and detection strategy with recombinant antigens. The 1° MAbs (vertical axis) are covalently linked to magnetic microspheres. 2° MAbs (horizontal axis) are biotinylated, and detection is achieved with SAPE. Clade I MPXV A29 is shown in (A), and Clade II MPXV A29 is shown in (B). Clade selectivity of down-selected MAb pairs using 2°-biotin conjugate, as shown in (C), and 2°-PE conjugate, as shown in (D). Data are presented as signals using MPXV A29 divided by signals using VACV A27.