Table 5.
Anticancer activity of microbe-mediated ZnO-NPs.
| Microbes | Toxicity against cell lines | Activity (IC50 Value) | Reference |
|---|---|---|---|
| Bacteria | |||
| R. pyridinivorans | Colon Cancer (HT-29) | – | Kundu et al. (2014) |
| Streptomyces sp. | Lung Cancer (A549) | 15.6 μg mL−1 | Balraj et al. (2017) |
| Lactobacillus spp. | Colon Cancer (HT-29) | 54.16 μg mL−1 | Suba et al. (2021) |
| Actinomycetes | |||
| Streptomyces sp. | Human Osteosarcoma (MG63), Vero cells | 200 μg mL−1 | Shanmugasundaram and Balagurunathan (2017) |
| Fungi | |||
| A. alternata | Human Lymphocyte Cells | ≥500 μg mL−1 | Sarkar et al. (2014) |
| A. terreus | Human Colorectal Adenocarcinoma (Caco-2), Normal Vero (kidney of African green monkey), Normal Rat Liver Epithelial (Colne-9) | 26.85–79.57 μgmL−1 | Fouda et al. (2018) |
| A. niger | Human Breast Carcinoma (MCF-7) | 38–50 μg mL−1 | Es-haghi et al. (2019) |
| A. niger | Liver Cancer (HepG2), Human Embryonic Kidney (HEK-293) (non-cancerous) | 19.16–26.75 μgmL−1 | Gao et al. (2019) |
| F. keratoplasticum | Human Colorectal Adenocarcinoma (Caco-2), Normal Vero (kidney of African green monkey), Normal Rat Liver Epithelial (Colne-9) | 20.1–104.3 ppm | Mohamed et al. (2019) |
| A. niger | 57.6–131 ppm | ||
| A. tenuissima | Normal Human Melanocytes (HFB-4), Hepatocelluar Carcinoma (HepG-2), Human Breast Carcinoma (MCF-7) | 16.87–55.76 μg mL−1 | Abdelhakim et al. (2020) |
| X. acuta | Human Mammary Gland Carcinoma (MDA-MB 134) | 1 μgmL−1 | Sumanth et al. (2020) |
| A. niger | Human Breast Carcinoma (MCF-7), Skin Fibroblast Cells | – | Es-haghi et al. (2021) |
| A. niger | Wi-38 Cells | ~800.42 μg mL−1 | Mekky et al. (2021) |
| Yeast | |||
| P. kudriavzevii | Vero Cells | 190–238 μg mL−1 | Moghaddam et al. (2017) |