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. 2023 Sep 8;15:1194203. doi: 10.3389/fnagi.2023.1194203

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Copyright © 2023 Bedoya-Guzmán, Pacheco-Herrero, Salomon-Cruz, Barrera-Sandoval, Gutierrez Vargas, Villamil-Ortiz, Villegas Lanau, Arias-Londoño, Area-Gomez and Cardona Gomez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Discrimination of the lipid profile of the hippocampus from cognitive improvement in an animal model silenced for BACE1 and SCD1 genes. Multivariate analyses of the lipid profiles from the A–D hippocampus. Score plots of PLS-DA and partial least squares analysis to discriminate between the lipid classes also show the projections of the data with the sMC and VIP metrics and values from sMC and VIP in a table per item. The variables in the analyses are as follows: Sham ScrBACE1-scrSCD1, Sham shBACE1-scrSCD1, Sham scrBACE1-shSCD1, Sham shBACE1-shSCD1; Isch ScrBACE1-scrSCD1, Isch shBACE1-scrSCD1, Isch scrBACE1-shSCD1, Isch shBACE1-shSCD1. PA, phosphatidic acid; PC, phosphatidylcholine; LPC, lysophosphatidylcholine; ePC, ether phosphatidylcholine; PS, phosphatidylserine; ePS, ether phosphatidylserine; PE, phosphatidylethanolamine; LPE, lysophosphatidylethanolamine; ePE, ether phosphatidylethanolamine; PI, phosphatidylinositol; PG, phosphatidylglycerol; SM, sphingomyelin, n = 5 per group.