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. 2023 Sep 22;9(38):eadg1391. doi: 10.1126/sciadv.adg1391

Table 4. IRs of unexpected vaginal bleeding per 100 PYs and HRs with 95% CIs in the first 4 weeks after vaccination (first or second dose), by vaccine type (i.e., Comirnaty versus Spikevax).

cHR, crude HR; aHR, HR adjusted for age.

Events PY IR per 100 PY (95% CI) cHR (95% CI) aHR (95% CI)
Postmenopausal (n = 7463)
Comirnaty 91 823 11.1 (9.0–13.6) Ref Ref
Spikevax 18 207 8.7 (5.5–13.8) 0.82 (0.49–1.37) 0.95 (0.57–1.59)
Perimenopausal (n = 6617)
Comirnaty 396 672 58.9 (53.4–65.0) Ref Ref
Spikevax 99 147 67.3 (55.3–82.0) 1.08 (0.87–1.36) 1.08 (0.87–1.36)
Premenopausal (n = 6592)
Comirnaty 388 660 58.8 (53.5–65.0) Ref Ref
Spikevax 98 124 79.3 (65.1–96.7) 1.30 (1.03–1.62) 1.32 (1.05–1.65)