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. 2023 Sep 22;9(38):eadh7969. doi: 10.1126/sciadv.adh7969

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Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4. — (A) Antibody neutralizing activity was assessed by measuring the capacity of plasma to inhibit SARS-CoV-2 spike protein binding to its receptor (ACE2). The frequency of patients displaying a neutralizing antibody response (>50% neutralization at 1/80 dilution) is shown for both groups of patients (GG and AA + GA genotypes), at both time points. Statistical significance of the differences between the two groups of patients is shown on top (Mann-Whitney test). (B) The percentage of neutralization by patients’ plasma at the acute phase of the infection correlates with the frequency of triple-positive CD69⁺CD4⁺ T cells after in vitro stimulation with a selected pool of SARS-CoV-2 peptides. The correlation coefficient (Spearman’s r) and the associated probability (P) are shown.