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. 2023 Sep 22;9(38):eadj1736. doi: 10.1126/sciadv.adj1736

Fig. 1. SARS-CoV-2 Omicron BA.5–induced lethality in K18-hACE2 transgenic mice is exacerbated with age.

Fig. 1.

(A) Three-month-old K18-hACE2 mice (BA.1 n = 8, BA.5 n = 9) were infected with 3.25 × 104 PFU SARS-CoV-2 Omicron BA.1 or BA.5, and weight was monitored daily. (B) Percent survival following SARS-CoV-2 Omicron BA.1 or BA.5 infection. (C) Five- to 8-month old K18-hACE2 mice (BA.1 n = 3, BA.5 n = 8) were infected with 3.25 × 104 PFU SARS-CoV-2 Omicron BA.1 or BA.5, and weight was monitored daily. (D) Percent survival following SARS-CoV-2 Omicron BA.1 or BA.5 infection. Two-way analysis of variance (ANOVA) with Sidak’s multiple comparisons test (A and C). ****P < 0.0001. Log-rank (Mantel-Cox) test (B and D).