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. 2023 Sep 6;14:1231749. doi: 10.3389/fimmu.2023.1231749

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Copyright © 2023 Cooray, Price-Kuehne, Hong, Omoyinmi, Burleigh, Gilmour, Ahmad, Choi, Bahar, Torpiano, Gagunashvili, Jensen, Bellos, Sancho-Shimizu, Herberg, Mankad, Kumar, Kaliakatsos, Worth, Eleftheriou, Whittaker and Brogan

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Shedding assay results. CD62L shedding was assessed by flow cytometry results for CD11b positive granulocytes from affected patients A-II-1, A-II-2, and B-II-3 and healthy adult controls following Toll-like receptor (TLR) agonists LPS (TL4), MALP-2 (TLR2/6), Flagellin (TLR5), PAM3CSK5 (TLR1/2) and R-848 (TLR7/8) stimulation. Phosphate buffered saline (PBS) and phorbolmyristyl acetate (PMA) were used as negative and positive controls, respectively. The percentage of gated granulocytes that have shed CD62L is indicated in the top left-hand quadrant.