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. 2023 Sep 6;17:1257803. doi: 10.3389/fncel.2023.1257803

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Copyright © 2023 Feldmeyer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified diagram of the synaptic connectivity in the parietal association cortex (PtA). The PtA L6b connectivity diagram was derived from stimulations of L6b excitatory neurons with co-applications of orexin-B and nicotine that resulted in AP firing of these neurons. In the Pta, synaptic input from multipolar PtA L6b neurons (color-coded in black) to all cortical layers was identified. Furthermore, ipsilateral long-range synaptic connections predominantly to layer 6a CC PCs (red) and 5 of adjacent cortical areas were also found. In addition, orexin/nicotine-activated synaptic input to contralateral L5 PCs was also recorded. Furthermore, L6b and L6a excitatory neurons received thalamocortical input from the Rhomboid thalamic nucleus (magenta). Furthermore, a dense network between L6b excitatory neurons, nFS (green), and L6 FS (PV+) interneurons (blue) was identified (indicated by the dashed circle). Simplified diagram of the synaptic connectivity in the parietal association (PtA) cortex. Different arrow heads signify: ▶ synaptic input to S1 layer 6b; >synaptic output from S1 layer 6b; inhibitory input is marked by bars. See main text for details).