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. 2023 Sep 6;14:1211015. doi: 10.3389/fendo.2023.1211015

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Copyright © 2023 Lamichhane, Sen, Dickens, Kråkström, Ilonen, Lempainen, Hyöty, Lahesmaa, Veijola, Toppari, Hyötyläinen, Knip and Orešič

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Polar metabolite profiles in serum during the follow-up. (A-D) Local polynomial regression fitting (LOESS) curve plot of metabolite concentration over time for the two study groups. Blue, Slow Progressors, SP; red, Rapid Progressors. Solid line, mean value; shaded area, 95% CI. e) Age matched comparison of polar metabolite between SP and RP. The plot shows the most discriminating metabolites between the two study groups compared using multivariable linear model (metabolite ~ sex +case), where case indicate (SP vs. RP). Red and blue colors signify linear correlation coefficient up-, down-regulation SP vs. RP.