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. 2023 Sep 7;14:1210517. doi: 10.3389/fmicb.2023.1210517

FIGURE 1.

FIGURE 1

Phloretin improved pathological injury, hepatic lipid deposition and insulin resistance in western diet (WD) fed mice (n = 6). (A) Schematic diagram illustrating treatment regimen. (B) Representative images of liver along with H&E (scale bars, 200 μm; black arrows represent macrosteatosis, blue arrows represent microsteatosis, and red arrows represent inflammatory focci), Oil Red O staining (scale bars, 100 μm) from each group and Picrosirius red staining (scale bars, 100 μm; red color represent fibrous tissues). (C) Graphical representation of semi-quantitative scoring of MAFLD in different groups. (D) Graphical representation of weekly food intake in different groups. (E) Graphical representation of body weight gain in different groups. (F) Blood glucose level in different groups. (G) Serum insulin level in different groups. (H) Graphical representation of HOMA-IR in all groups. The symbols “#,” “##,” “###” represent p < 0.05, p < 0.01, and p < 0.001, respectively vs. control group; the symbols “**,” “***” represent p < 0.01, p < 0.001, respectively vs. WD group.