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. 2023 Sep 7;14:1210517. doi: 10.3389/fmicb.2023.1210517

FIGURE 2.

FIGURE 2

Phloretin maintained serum lipid profile, metabolic homeostasis and decreased the inflammatory markers in WD fed mice (n = 6). Panels (A–D) denote the impact of phloretin on serum triglycerides, cholesterol, LDL-C, and HDL-C level, respectively. (E) Quantitative representation of the gene expression of SREBP-1c, ChREBP, FASN, and CD36, respectively in each group. (F) Quantitative representation of the gene expression of PPAR-γ and PPAR-α, respectively in each group. Panels (G,H) represent the serum concentrations of IL-6 and TNF-α level, respectively. (I) mRNA expression of IL-6 and TNF-α in liver tissue from different groups. (J) Fecal endotoxin level in all group at different time points. The symbols “#,” “##,” “###” represent p < 0.05, p < 0.01, p < 0.001, respectively vs. control group; the symbols “*,” “**,” “***” represent p < 0.05, p < 0.01, p < 0.001, respectively vs. WD group; ns represents non-significant.