TABLE 1.

In vitro activity of fluconazole against 402 clinical yeast isolates as determined by the reference broth microdilution method^a

Organism	No. of isolates tested	MIC (μg/ml)b
		Range	50%	90%
C. albicans	161	0.25–64	1.0	4.0
C. glabrata	41	1.0–256	32	128
C. tropicalis	35	0.5–8.0	2.0	4.0
C. parapsilosis	29	0.25–64	4.0	32
C. krusei	32	2.0–64	64	64
C. lusitaniae	31	0.25–256	2.0	8.0
Candida speciesc	19	1.0–128	4.0	64
Cryptococcus neoformans	40	2.0–32	8.0	16
Miscellaneous speciesd	14	1.0–>256	4.0	>256
All	402	0.25–>256	4.0	64

^aPerformed according to NCCLS M27-A (7). 

^b50% and 90%, MICs at which 50 and 90% of isolates tested, respectively, are inhibited. 

^cIncludes C. guilliermondii (n = 5), C. lipolytica (n = 4), C. rugosa (n = 5), C. kefyr (n = 2), and C. zeylanoides (n = 3). 

^dIncludes Cryptococcus laurentii (n = 2), C. albidus (n = 1), T. beigelii (n = 4), Rhodotorula spp. (n = 4), and S. cerevisiae (n = 3).