. 2023 Feb 18;37(14):2950–2955. doi: 10.1038/s41433-023-02447-6

Table 2.

Corneal sensitivity thresholds and corneal nerve and LC parameters in patients with rheumatoid arthritis (RA) and healthy control participants.

	Control subjects (n = 35)	Patients with RA (n = 50)	P value
Central corneal sensitivity (cm), median (IQR)	6.0 (6.0–6.0)	6.0 (5.5–6.0)	0.010^a
CNFD (no./mm²), mean ± SD	34.5 ± 7.3	30.8 ± 6.7	0.020^b
CNBD (no./mm²), median (IQR)	60.4 (52.1–77.1)	45.8 (29.2–58.8)	<0.001^a
CNFL (mm/mm²), mean ± SD	22.4 ± 3.5	18.5 ± 4.0	<0.001^b
LC density (no./mm²), median (IQR)	14.6 (4.2–31.3)	35.4 (12.0–57.3)	0.003^a
Mature LC density (no./mm²), median (IQR)	0 (0–4.2)	5.2 (0–15.3)	0.001^a
Immature LC density (no./mm²), median (IQR)	10.4 (2.1–29.1)	21.9 (7.8–45.8)	0.011^a

CNFD corneal nerve fibre density, CNBD corneal nerve branch density, CNFL corneal nerve fibre length, LC Langerhans cell.

^aMann–Whitney U-test.

^bIndependent samples t-test.