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. 2023 May 9;48(11):1602–1611. doi: 10.1038/s41386-023-01588-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Dose-specific subjective effects of LSD measured with the Altered States of Consciousness Rating Scale, in which questionnaire items are organized into five factors, called ‘dimensions’ of altered states of consciousness experiences (5D-ASC). B A finer-grained quantification of specific aspects of subjective experiences is obtained when the questionnaire is analyzed according to the 11-factors schema. These 11 factors can be considered subscales of the three core dimensions of the 5D-ASC (see corresponding colors of the subscale names). Doses are given in microgram, as absolute doses not normalized to body weight; effects are given as the percentage score of the maximum score on each factor (questionnaire items were anchored with 0% for ‘No, not more than usual’ and 100% for ‘Yes, much more than usual’). Circle color indicates from which article the data was obtained; the same color of two circles indicates statistically dependent data. Circle size corresponds to the weight of a study based on study variance (see Methods). Radar charts present the estimated dose-responses for doses up to 200 μg. The color of individual scales corresponds to the primary dimensions and the respective subscales.