Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 22;14:5901. doi: 10.1038/s41467-023-41654-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Electrostatic potential of the lysoPS binding surface colored from red to blue for negatively and positively charged regions. b GPR174 shows perfect shape complementarity with lysoPS. The surface of interior pocket of GPR174 is shown in gray. c Detailed interactions between GPR174 and lysoPS. d and e Concentration–response curves of GPR174 mutants treated with increasing concentrations of lysoPS in the cAMP accumulation assay (d) and the NanoBiT Gαs recruitment assay (e). All measurements were performed in three independent times, shown as mean ± SEM. Source data are provided as a Source Data file. f Concentration–response curves of GPR174/Y99^3.33A mutants treated with different LPs in the cAMP accumulation assay. Each data point represents mean ± SEM from three independent experiments. Source data are provided as a Source Data file.