Table 1.

Description of the model parameters and the source of their values.

Symbol	Description	Source	Pre-intervention value	Post-intervention value
H	Number of HCWs during a time-shift	Clinical data	17	17
KH	Per-capita contact rate (daily contacts per HCW per patient)	Calculated as a function of h17,37 (see Supplementary Table S3)	0.776 ± 0.008	0.964 ± 0.009
h	Hand hygiene compliance	Fitted on point prevalence time series	0.855 ± 0.008	0.868 ± 0.008
$A\left(\epsilon ,,,\xi \right)$	Increase in transmission probability by antibiotic consumption	Clinical data Literature16,29	1.50	1.28
ε	Treatment duration (LOS fraction)	Clinical data	0.23	0.15
ξ	Increased risk of acquiring resistance due to antibiotic pressure	Literature29	3.15	2.94
d	Average discharge rate (inverse of LOS)	Clinical data	1/10.6 days−1	1/9.2 days−1
a	Admission rate (new patients per day)	Clinical data	3.4 per day	3.6 per day
pF	PF fraction at admission	Clinical data	0.969	–
pS	PS fraction at admission	Clinical data	0.025	–
pR	PR fraction at admission	Clinical data	0.006	–
μH	Clearance rate for HCWs (inverse of contamination)	Assuming contamination to last 1 h	24 days−1	–
γ	Probability of KP contamination P → HCW per single contact	Literature17	0.21	–
α	Probability of KP transmission HCW→ P per single contact	Literature21	0.45	–
q	Fraction of HCWs allocated to cohorting	Fitted on point prevalence time series	0.10 ± 0.07	0.10 ± 0.07
ωRF	Decolonization rate of PR (inverse of colonization duration)	Literature18	1 month−1	–
ωSF	Decolonization rate of PS (inverse of colonization duration)	Literature18	1 month−1	–

Parameters value is reported both for the pre- and post-intervention periods.

HCW health care workers, P patients, KP Klebsiella pneumoniae, LOS length of hospital stay, P_F not colonized/free, P_R colonized/infected by resistant strain, P_S colonized/infected by susceptible strain.