Fig. 1.

Infusion of saline, aspirin, ticagrelor, or Tyrode buffer supplemented with apyrase and prostaglandin E₁ does not impact on infarct size. Solutions were infused into isolated perfused rat hearts subjected to 30-min global ischemia and 120-min reperfusion. The concentrations for infusion with aspirin (40 µmol/L, n = 8) and ticagrelor (10 µmol/L, n = 8) were chosen to reflect the expected maximum plasma concentration 2–3 h after oral ingestion of aspirin and ticagrelor, respectively, in healthy volunteers. The concentration of apyrase and prostaglandin E₁ (0.1 U/mL and 1 µmol/L, n = 8) was equal to that used for the preparation of washed platelet solutions. Infusion of saline (n = 10) served as control