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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: J Biomed Mater Res A. 2023 Mar 23;111(9):1372–1378. doi: 10.1002/jbm.a.37539

FIGURE 3.

FIGURE 3

Treatment with paKG MPs results in faster wound closure and higher ultimate tensile strength (UTS). (A) The wound area (normalized to day 0) is shown, which demonstrates that the 1,10-paKG microparticles close the wound within 10 days (n = 6, avg ± SEM, *p < .05, significantly different than all other groups, One-way ANOVA). (B) The ultimate tensile strength (UTS) and % strength as compared to the intact skin was found to be highest for 1,10-paKG microparticles and lowest for soluble aKG group on day 10 (n = 6, avg ± SEM, *p < .05, significantly different than all other groups). (C) Picrosirius staining performed on the skin tissue isolated from the wound bed demonstrated that the paKG MPs allowed for deposition of collagen type III (green, dashed arrow) and collagen type I (red, solid arrow) in the tissue (scale bar = 330 μm, n = 3 mice per group, 3 technical replicates). (D) H&E performed on the skin tissue isolated from the wound bed demonstrated that the paKG MPs decreased immune cell infiltration in the wound bed.