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. 2023 Sep 22;14:5920. doi: 10.1038/s41467-023-41631-w

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Experimental schema of the Panc-1 metastasis xenograft mouse model (created with BioRender.com). n = 7/8 mice/group. b, c Representative tumor bioluminescence images of mice b and tumor growth curve c measured by bioluminescence. n = 7/8 mice/group. ***P < 0.001, two-tailed unpaired Student’s t test. d Experimental schema of the Panc-1 metastasis xenograft mouse model under tumor-rechallenge (created with BioRender.com). n = 5/7 mice/group. Three mice were used as the control. e, f Representative tumor bioluminescence images of mice e and tumor growth curve f. n = 5/7 mice/group. ***P < 0.001, two-tailed unpaired Student’s t test. g Kaplan-Meier survival curve post-CAR-T cells infusion. ***P < 0.001, Log-rank test. h Tumor metastasis images in mice infused with CD19 or B7-H3 CAR-T cells. Mouse tissues and tumors (GFP) were visualized by the white and UV/blue light, respectively. i Dose-dependent effects of B7-H3 CAR-T cells in the Panc-1 metastasis mouse model (created with BioRender.com). n = 3/5 mice/group. j, k Tumor bioluminescence growth curve with 5 million (j) or 2.5 million (k) B7-H3 CAR-T cells. **P = 0.007, ***P < 0.001, two-tailed unpaired Student’s t test. l Absolute CAR-T count from 100 μl blood was identified in mouse peripheral blood after week 2/3/4 of infusion. n = 3 individual samples/group. Values represent mean ± SEM. *P = 0.16, two-tailed unpaired Student’s t test. m PD-1 expression in circulated CD3⁺CAR-T cells at week 2/3/4 of infusion. n = 3 individual samples/group. Values represent mean ± SEM. ***P = 0.0006, two-tailed unpaired Student’s t test. n Distribution of memory subsets in CD4⁺/CD8⁺ CAR⁺-T cell subpopulations at week 6 of infusion^. n = 3 individual samples/group. Values represent mean ± SEM. o Experimental schema of the Panc-1 orthotopic mouse model (created with BioRender.com). n = 4 mice/group. p Tumor bioluminescence images of orthotopic Panc-1 mice (created with BioRender.com) in the CAR-T treatment groups. CAR-T cells from donor #076’s PBMC. Source data is provided as a Source Data file.