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. 2023 May 25;48(11):1659–1667. doi: 10.1038/s41386-023-01607-2

Fig. 3. Acute autonomic effects.

Fig. 3

The high 500 mg mescaline dose, LSD, and psilocybin similarly increased systolic blood pressure, heart rate, body temperature, and the rate pressure product. LSD showed a significantly lower maximal diastolic blood pressure response compared with psilocybin. Conversely, LSD showed a trend toward an increase in heart rate compared with psilocybin. The data are expressed as the mean ± SEM of maximum responses in 32 participants for LSD and psilocybin and in 16 participants for each mescaline dose. The corresponding statistics are shown in Supplementary Table S5.