Table 1.
Characteristics of the subjective response to Mescaline, LSD, and Psilocybin.
| Effect | Mescaline 300 mg | Mescaline 500 mg | LSD 100 µg | Psilocybin 20 mg |
|---|---|---|---|---|
| n = 16 | n = 16 | n = 32 | n = 32 | |
| Time to onset (h) | 0.8 ± 0.5+***## (0.4–1.9) | 0.9 ± 0.6+# (0.1–2.7) | 0.4 ± 0.2 (0.0–1.0) | 0.5 ± 0.3 (0.1–1.3) |
| Time to offset (h) | 10.5 ± 1.9+### (7.4–14) | 12.0 ± 3.4+**### (7.9–22) | 8.6 ± 3.0### (4.9.–19) | 5.3 ± 1.7 (3.0–11) |
| Time to maximal effect (h) | 4.0 ± 1.3+***### (3.1–8.0) | 3.4 ± 1.2+*## (1.4–6.0) | 2.3 ± 1.0 (0.75–4.0) | 2.1 ± 1.0 (0.5–4.0) |
| Effect duration (h) | 9.7 ± 2.2+## (5.6–13) | 11.1 ± 3.8+*### (6.0–22) | 8.2 ± 3.1### (4.3.–19) | 4.9 ± 1.7 (2.6–10) |
| Maximal effect (%) | 58 ± 31*# (0–100) | 86 ± 27 (6–100) | 83 ± 21 (29–100) | 87 ± 17 (43–100) |
| AUEC | 319 ± 223 (0–671) | 616 ± 339### (2.8–1507) | 423 ± 205# (64–863) | 267 ± 91 (91–472) |
Parameters are for “any drug effect” as determined using the individual effect-time curves. The threshold to determine times to onset and offset was set to 10% of the individual maximal response. Values are mean ± SD (range). *P < 0.05, **P < 0.01, ***P < 0.001 compared with LSD; #P < 0.05, ##P < 0.01, ###P < 0.001 compared with psilocybin; Tukey tests; +n = 15; AUEC, area under the effect curve.