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. 2023 Apr 17;146(7):2957–2974. doi: 10.1093/brain/awad037

Figure 4.

Figure 4

Astrocytic MCT1 gene-silencing reduces tonic inhibition and spike probability in the hippocampus of an AD mouse model. (A) Representative traces of tonic GABA recording from hippocampal dentate granule cells of 5xFAD and WT littermates. (B) Quantification of tonic GABA current (n = 15, 10, 9 and 9 cells from three mice for each group). (C) Representative traces of spontaneous inhibitory postsynaptic current (sIPSC) recording. (D and E) Quantification of sIPSC frequency and amplitude (n = 12, 10, 7 and 8 cells from three mice for each group). (F) Schematic diagram of action potential recording from dentate granule cells upon electrical stimulation of hippocampal perforant path (left) and representative traces of spike probability. (G) Quantification of spike probability upon various stimulation intensities (n = 11, 18, 12 and 15 cells from three mice for each group). (H) Quantification of spike probability at 600 μA stimulation. Mean ± SEM. Significance was assessed by one-way ANOVA with Tukey.