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. 2023 Sep 19;34(17-18):947–957. doi: 10.1089/hum.2023.005

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Copyright 2023, by Mary Ann Liebert, Inc., publishers

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Figure 4. — Kinetic effect of CEM87 on transgene expression and FK506-reversibility of the transgene expression enhancement. (A) Diagram of time course and reversibility of CEM87 experiments in HEK293T cells. (B) Impact of CEM87 on AAV transgene activity over time after a single dose at time 0 h. (C) AAV transgene activity following CEM87 removal and the addition of FK506. (D) Dose-dependent effect of FK506 on chemical competition with CEM87 to suppress an CEM87-mediated increase in AAV transgene activity. p Value parameters: ***p ≤ 0.001, ****p ≤ 0.0001.