Table 3.
Drugs That Have Been Found to Induce Ferroptosis in Colorectal Cancer
| Drug | Models used | Ferroptosis effect | References |
|---|---|---|---|
| Apatinib | HCT116 cells | Promotes ferroptosis through targeting ELOVL6/ACSL4 pathway. | Tian et al. (2021) |
| IMCA | DLD-1 cells HCT116 cells CRC xenograft model |
Promotes ferroptosis. Downregulates expression of SLC7A11, leading to decreased substrates necessary for GPX4 to function and thus accumulation of lipid peroxides. Also inhibits mTOR/P70S6K activity. |
Zhang et al. (2020b) |
| TalaA | HCT116 cells SW480 cells SW620 cells CRC xenograft model |
Promotes ferroptosis. Increases ROS in cells to sensitize cells to ferroptosis and also downregulates expression of SLC7A11 and upregulates expression of ALOXE3. | Xia et al. (2020) |
| Honokiol | RKO cells HCT116 cells SW480 cells HT29 cells LS174T cells HCT8 cells SW48 cells |
Promotes ferroptosis. Increases ROS and Fe2+ levels. Decreases activity of GPX4; does not affect System Xc−. | Guo et al. (2020) |
| CNC | HCT116 cells | Promotes ferroptosis. Downregulates expression of GPX4 and upregulates expression of HMOX1. | Chen et al. (2021b) |
| Sulfasalazine | HCT116 cells HT29 cells LOVO cells DLD-1 cells |
Promotes ferroptosis. Inhibits System Xc− thus preventing GSH synthesis through limiting GPX4 activity. | Ma et al. (2015) |
| BSO | HCT116 cells VACO5 cells VACO6 cells VACO8 cells |
Promotes ferroptosis. Depletes GSH in cancer cells. | Berger et al. (1994) |
| DCA | HCT116 cells HT29 cells |
Promotes ferroptosis Sequesters iron in lysosome, triggering ferroptosis. |
Sun et al. (2021) |
| Oxaliplatin | HT29 cells | Promotes ferroptosis. Inhibits Nrf2 signaling pathway. | Liu and Wang (2022) |
| Matrine | HCT116 cells | Promotes ferroptosis. Increases ROS and Fe2+ levels. Downregulates expression of GPX4 and SLC7A11. | Wang et al. (2020a) |
ACSL4, acyl-CoA synthetase long-chain family member 4; BSO, buthionine sulfoximine; CNC, Camellia nitidissima Chi; DCA, dichloracetate; GPX4, glutathione peroxidase 4; IMCA, 2-imino-6-methoxy-2H-chromene-3-carbothioamide; TalaA, talaroconvolutin A.