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Number of 3′ and 5′ UTR variants by classification of clinical significance. (A) Total number of variants that proceeded to curation, stratified by clinical significance as reported by ClinVar submitters. (B) Total number of variants that proceeded to curation, stratified by clinical significance as classified in this study. LP, likely pathogenic; P, pathogenic; UTR, untranslated region; VUS, variant of uncertain significance.
