Figure 6.

Schematics for illustrating the relationships among microbubble (MB) concentration, vessel saturation rate, microbubble localization efficiency, and microvessel reconstruction fidelity. (a) A higher concentration of microbubbles will perfuse more vessels per unit time, leading to a faster vascular saturation rate. (b) Lower concentrations of microbubbles are more spatially sparse, making detection and localization easier. (c) Super-resolution ultrasound requires a “sweet spot” of microbubble concentration to enable accurate vessel reconstruction within a pragmatic amount of time.