Table 1.
Summary of existing in vivo preclinical and clinical studies using super-resolution ultrasound imaging
Organ | Condition | Imaging setting and model | Publication | Likelihood for transition to clinical research and practice |
---|---|---|---|---|
Brain | Stroke | Rat | Chavignon et al., 2022 [45] | Medium (non-neonates):
|
Brain | Stroke | Human | Demené et al., 2021 [44] | |
Brain | Alzheimer’s disease | Mouse | Lowerison et al., 2022 [47] | |
Brain | Aging | Mouse | Lowerison et al., 2022 [48] | |
Brain | Hydrocephalus | Pig | Zhang et al., 2022 [79] | |
Brain | Normal animal for functional neural activity imaging; normal animal for dynamic pulsatility measurement | Rat | Renaudin et al., 2022 [39]; Bourquin et al., 2022 [67]; McCall et al., [80] | |
Spinal cord | Normal | Rat | Claron et al., 2021 [81]; van Sloun et al., 2021 [34] | Low-medium:
|
Breast | Cancer | Human | Opacic et al., 2018 [21]; Huang et al., 2021 [62] | High:
|
Lymph Node | Normal | Rabbit | Zhu et al., 2019 [82] | High:
|
Lymph Node | Metastatic cancer | Human | Zhu et al., 2022 [61] | |
Tumor xenografts | Colorectal cancer; renal cell carcinoma; fibrosarcoma; lung carcinoma; epidermoid carcinoma; myxoid liposarcomas | Chicken embryo chorioallantoic membrane; rat; mouse | Lowerison et al., 2022 [50]; Lowerison et al., 2020 [49]; Lin et al., 2017 [18]; Opacic et al., 2018 [21] | N/A |
Pancreas | Cancer | Human | Huang et al., 2021 [62] | Medium:
|
Liver | Cancer | Rabbit | Zhang et al., 2021 [64] | Medium – High:
|
Liver | Normal and acute-on-chronic liver failure | Human | Huang et al., 2021 [62] | |
Kidney | Ischemia | Rat | Andersen et al., 2020 [23] | Medium – High:
|
Kidney | Acute injury | Mouse | Chen et al., 2020 [83] | |
Kidney | Normal | Human | Huang et al., 2021 [62] | |
Kidney | Transplant allograft | Human | Bodard et al., 2023 [73] | High:
|
Prostate | Unknown | Human | Solomon et al., 2019 [60] | High:
|
Heart | Normal | Isolated rat heart; in vivo rat heart (transthoracic imaging) | Demeulenaere et al., 2022 [65]; Cormier et al., 2021 [66] | Low-Medium:
|
Lower limb muscle | Normal | Human | Harput et al., 2018 [84] | High:
|
Vasa vasorum | Atherosclerotic plaques; Takayasu arteritis | Rabbit and human | Chen et al., 2020 [85]; Goudot et al., 2023 [86] | Medium - High:
|
Eye | Elevated intraocular pressure | Rabbit | Qian et al., 2022 [87] | Medium:
|