Table 2.

Summary of roadblocks for clinical translation of super-resolution ultrasound imaging

	Name of the challenge	Solutions
Critical roadblocks for clinical translation	Slow imaging speed/long data acquisition	Technical development for fast super-resolution imaging
	Tissue motion (especially for out-of-plane motion)	•Improve imaging speed to mitigate tissue motion •Use of 3D imaging to track 3D tissue motion •Develop new motion correction techniques
	Use of contrast microbubbles	Contrast-free solutions that provide enhanced spatial resolution (not as high as conventional super-resolution ultrasound that is localization-based)
“Soft” roadblocks for clinical translation	Slow imaging frame rate on conventional ultrasound scanners	•Designated high frame-rate imaging mode for super-resolution data acquisition; •Algorithm development for super-resolution imaging with low frame rate, conventional CEUS data
	Computational cost associated with beamforming and post-processing	Algorithm acceleration, optimization, and parallelization (e.g., GPU-based)