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. 2023 Aug 14;33(3):407–426. doi: 10.1016/j.zemedi.2023.04.007

Figure 5.

Figure 5

Treatment evaluation for multiple fraction experiments. Kaplan-Meier survival data for multiple fraction treatments, including 1% (v/v) microbubble and focused ultrasound exposure (USMB), multi-fraction radiation (XRT), and combined treatments (USMB + XRT). Animals with untreated tumors or control groups were also included. Animals received USMB treatments twice weekly, and XRT administration in a radiation-only group or combined treatment groups were delivered in five fractions/week at 2 Gy each over 3 weeks (BED10 = 30 Gy). The statistical test revealed a drop of zero in the mean survival after one week for the control group and USMB treatments, whereas 19% diminishment for the XRT group by the end of the third week. A drop of 88% was observed in the combined treatment group after the first week, which persisted for all subsequent weeks. The mean survival changes in the combined group were statistically significant compared to other groups. From [80].