Figure 9.

Power Doppler analysis of vascular changes in tumors as a result of Acid sphingomyelinase (ASMase) effects. (A) Maximum intensity projections of power Doppler signals within a 3D volumetric scan of whole tumors undergoing respective treatments. The color bar represents a range from 11dB (black) to 30dB (orange). Tumors underwent fractionated XRT alone or combined with ultrasound-stimulated microbubbles (USMB) treatments. Scans were collected 72 h after the final treatment day. (B), (C), and (D) Quantified vascular index percent change of signal in each treatment condition of wild-type (WT), S1P, and ASMase knockout groups. Error bars represent the standard error of the mean (SEM). All data underwent statistical analysis by Welch’s t-test, *p < 0.05. Preliminary data from [81].