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. 2023 Sep 23;24:226. doi: 10.1186/s12931-023-02534-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — A Total lung, B regional small airways, and C central lung deposition for ICS components of each treatment

***Nominal p < 0.001 (paired t-test) for BGF versus FF/UM/VI based on mean difference (95% CI): total lung, 33.0 (32.2–33.9); regional small airways, 12.8 (11.1–14.5); central lung, 20.2 (18.2–22.2)

Data labels: mean ± SD. Extremes of box: upper and lower quartiles. Horizontal line within box: median. Whiskers: extend to most extreme data points no more than 1.5 times the interquartile range. Individual data points beyond whiskers: outliers beyond 1.5 times the interquartile range

BGF, budesonide/glycopyrronium/formoterol fumarate dihydrate; CI, confidence interval; FF/UM/VI, fluticasone furoate/umeclidinium/vilanterol; ICS, inhaled corticosteroid; SD, standard deviation