Table 2.
Diagnostic value of using BALF or EBUS-GS with acid-fast staining, MGIT 960 culture, pathological examination, and Xpert for solitary pulmonary tuberculoma
| Clinical specimen | Sensitivity% (95%CI) | Specificity% (95%CI) | PPV% (95%CI) | NPV% (95%CI) | PLR (95%CI) | NLR (95%CI) | YI (95%CI) |
|---|---|---|---|---|---|---|---|
| BALF + acid-fast staining | 8.69 (4/46) | 100 (30/30) | 100 (4/4) | 41.67 (30/72) | – | 0.91 | 0.09 |
| 0.55–16.84 | 100–100 | 100–100 | 30.28–53.05 | 0.84–0.99 | 0.00–0.17 | ||
| BALF + MGIT 960 | 32.61 (15/46) | 100 (30/30) | 100 (15/15) | 49.18 (30/61) | – | 0.67 | 0.33 |
| 19.06–46.16 | 100–100 | 100–100 | 36.63–61.73 | 0.55–0.82 | 0.19–0.46 | ||
| BALF + Xpert | 34.78 (16/46) | 100 (30/30) | 100 (16/16) | 50.00 (30/60) | – | 0.65 | 0.35 |
| 21.02–48.55 | 100–100 | 100–100 | 37.35–62.65 | 0.53–0.81 | 0.21–0.49 | ||
| BALF + Xpert + MGIT 960 | 36.96 (17/46) | 100 (30/30) | 100 (17/17) | 50.85 (30/59) | – | 0.63 | 0.37 |
| 23.01–50.91 | 100–100 | 100–100 | 38.09–63.60 | 0.51–0.79 | 0.23–0.51 | ||
| EBUS-GS + acid-fast staining | 17.19 (11/64) | 100 (71/71) | 100 (11/11) | 57.26 (71/124) | – | 0.83 | 0.17 |
| 7.94–26.43 | 100–100 | 100–100 | 48.55–65.97 | 0.74–0.93 | 0.08–0.26 | ||
| EBUS-GS + MGIT 960 | 35.94 (23/64) | 100 (71/71) | 100 (23/23) | 63.39 (71/112) | – | 0.64 | 0.36 |
| 24.18–47.69 | 100–100 | 100–100 | 54.47–72.31 | 0.53–0.77 | 0.24–0.48 | ||
| EBUS-GS + pathological examination | 46.88 (30/64) | 95.77 (68/71) | 90.91 (30/33) | 66.67 (68/102) |
11.09 3.56–34.61 |
0.55 | 0.43 |
| 34.65–59.10 | 91.10–100 | 81.10–100 | 57.52–75.82 | 0.44–0.70 | 0.30–0.56 | ||
| EBUS-GS + Xpert | 57.81 (37/64) | 100 (71/71) | 100 (37/37) | 72.45 (71/98) | – | 0.42 | 0.58 |
| 45.71–69.91 | 100–100 | 100–100 | 63.60–81.29 | 0.32–0.56 | 0.46–0.70 | ||
| EBUS-GS + Xpert + MGIT 960 | 62.50 (40/64) | 100 (71/71) | 100 (40/40) | 74.74 (71/95) | – | 0.38 | 0.63 |
| 50.64–74.36 | 100–100 | 100–100 | 66.00–83.47 | 0.27–0.51 | 0.51–0.74 | ||
| EBUS-GS + Xpert + pathological examination | 62.50 (40/64) | 95.77 (68/71) | 93.02 (40/43) | 73.91 (68/92) |
14.79 4.81–45.50 |
0.39 | 0.58 |
| 50.64–74.36 | 91.10–100 | 85.41–100 | 64.94–82.89 | 0.28–0.54 | 0.46–0.71 |
BALF bronchoalveolar lavage fluid; MGIT Mycobacteria Growth Indicator Tube; EBUS-GS endobronchial ultrasound with guide-sheath; PPV positive predictive value; NPV negative predictive value; PLR positive likelihood ratio; NLR negative likelihood ratio; YI Youden index; CI confidence interval