Fig. 6.

METTL3 knockdown inhibited the malignant phenotype of A549 cells in vitro. A, B CCK8 (A) and EdU (B) assays were used to assess cell viability and proliferation. C Colony formation assays. D The scratch assay experiments on A549 cells. E, F Cell migratory and invasive abilities were detected using transwell assays in A549 cells. G METTL3 knockdown inhibited the growth of subcutaneous xenografts in vivo (top left), the tumor growth curve (low left), and the weight of tumors xenografted in nude mice (right). Bar = mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001