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. 2023 Sep 23;7:97. doi: 10.1038/s41698-023-00453-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Aneuploidy score for lower grade astrocytoma (n = 11) and their recurrence. b Aneuploidy score for grade 4 astrocytoma (n = 8) and their recurrence. c Aneuploidy score for GB (n = 46) and their recurrence. Points in light blue color represent primary samples, and in dark blue represent recurrent samples. d Boxplot of aneuploidy score for the primary and recurrent lower grade astrocytoma, grade 4 astrocytoma and GB. e Aneuploidy score difference (recurrent - primary) between primary and recurrent samples for lower grade astrocytoma, grade 4 astrocytoma and GB. For boxplots in (d) and (e), the upper and lower boundaries represent the first and third quantiles, respectively. The horizontal lines represent the median, and the whiskers denote the lowest and highest values except for outliers (black dots). Overall survival for primary lower grade astrocytoma (f), grade 4 astrocytoma (g) and GB patients (h) with small or large aneuploidy changes. Survival analysis was performed with the combination of our data (n = 49) and data downloaded from cBioPortal (n = 187). Cases with aneuploidy difference bigger than 3 or smaller than −3 was classified into large change group, others were classified into small change group. P values were obtained from the log-rank test.