TABLE 1.
Clinical characteristics and laboratory data for 36 patients with early and late skin borreliosisa
| Patient no. (gender and age) | Tick bite | Diagnosis (localization)b | Result by:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Serology
|
Culture | PCR
|
|||||||||
| ELISA
|
Western
blotting
|
PET
|
FFT
|
||||||||
| IgM | IgG | IgM | IgG | PCR I | PCR II | PCR I | PCR II | ||||
| 1 (M, 46) | + | EM (back of knee) | − | − | ND | ND | ND | − | − | + | + |
| 2 (F, 75) | + | EM (back of knee) | − | − | ND | ND | + | + | + | + | + |
| 3 (M, 57) | − | EM (back of knee) | − | + | (+) | + | ND | − | − | + | + |
| 4 a (M, 41)c | + | MEM (forearm) | + | − | + | + | + | NA | NA | + | + |
| 4 b | MEM (hip) | + | NA | NA | + | + | |||||
| 5 (M, 56) | + | EM (elbow) | − | − | ND | ND | + | + | + | + | + |
| 6 (F, 51) | + | EM (mamma) | − | − | ND | ND | + | + | + | + | + |
| 7 (M, 28) | − | EM (back of knee) | + | + | + | + | ND | − | − | − | + |
| 8 (F, 27) | − | EM (back of knee) | + | − | (+) | − | ND | − | + | + | + |
| 9 (M, 51) | + | EM (thigh) | (+) | − | + | + | ND | + | + | + | − |
| 10 (M, 47) | + | EM (heel) | + | + | + | (+) | + | NA | NA | + | − |
| 11 (F, 57) | − | EM (flank) | + | − | + | + | − | + | − | + | + |
| 12 (F, 47) | + | EM (foot) | + | − | − | − | ND | + | + | − | + |
| 13 (M, 54) | − | EM (back of knee) | − | − | ND | ND | − | − | − | + | + |
| 14 a (M, 31)c | + | MEM (upper arm) | + | + | + | (+) | + | NA | NA | + | + |
| 14 b | MEM (thigh) | + | NA | NA | + | + | |||||
| 15 (M, 41) | − | EM (back knee) | + | − | + | − | + | − | + | I | I |
| 16 (F, 60) | − | ECM (thigh) | + | (+) | + | − | + | I | I | + | − |
| 17 (F, 54) | − | ECM (ear) | + | − | + | + | ND | − | − | + | + |
| 18 (F, 38) | − | ECM (thigh) | + | + | (+) | (+) | ND | − | − | − | + |
| 19 (F, 41) | − | ECM (lower leg) | − | + | (+) | + | ND | − | − | − | − |
| 20 (M, 72) | − | ECM (abdomen) | + | − | + | + | ND | − | − | − | + |
| 21 (M, 52) | − | ECM (back) | (+) | + | + | + | + | − | − | − | + |
| 22 (F, 66) | + | ECM (shoulder) | + | + | (+) | (+) | + | NA | NA | + | + |
| 23 (F, 44) | − | ECM (thigh) | + | + | + | (+) | ND | − | + | + | + |
| 24 (F, 63) | + | ECM (breast) | − | + | − | + | ND | − | − | − | − |
| 25 (M, 38) | − | ECM (abdomen) | + | + | (+) | (+) | + | + | + | + | + |
| 26 (M, 57) | + | ECM (thigh) | − | − | ND | ND | + | + | + | + | + |
| 27 (M, 58) | − | ECM (thigh) | + | + | + | (+) | + | + | + | + | + |
| 28 (F, 55) | + | ECM (abdomen) | + | − | + | − | ND | + | + | + | + |
| 29 (M, 26) | − | ECM (thigh) | − | + | − | − | − | NA | NA | + | + |
| 30 (M, 64) | − | ECM (back) | − | − | ND | ND | ND | + | + | I | I |
| 31 (F, 56) | + | ECM | − | − | ND | ND | − | NA | NA | + | + |
| 32 (M, 55) | − | ACA (lower leg) | − | + | + | + | ND | − | − | + | + |
| 33 (F, 75) | − | ACA (hand) | (+) | + | + | + | − | − | − | − | + |
| 34 (M, 52) | − | ACA (hand) | (+) | + | + | + | − | + | + | + | + |
| 35 (F, 43) | − | ACA (lower leg) | + | + | − | (+) | ND | − | − | − | + |
| 36 (M, 76) | + | ACA (lower leg) | − | + | − | + | ND | − | − | − | − |
a
+, positive result; (+), borderline-positive reaction; −, negative result; NA, not available; ND, not done; I, inhibition.
b
Clinically and histologically confirmed diagnosis.
c
Two biopsies were done for patient no. 4 and 14.