Figure 1.
Occurrence (%) of spasticity, extrapyramidal signs or ataxia in a combination with developmental delay or impairment or regression in 13 categories of IEMs. The percentages for neurological involvement were calculated using as the denominator the total number of IEMs in each category presenting with spasticity, extrapyramidal signs or ataxia. Heat scale ranges from red (0%) for diseases with no particular symptoms reported to violet (100%) for diseases with particular symptoms occurring with highly frequency. For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.