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. 2023 Sep 23;21:346. doi: 10.1186/s12951-023-02085-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — miR-146b-5p silencing attenuated the effect of aged exosomes with zinc (AZ-EXOs) in bone marrow monocytes (BMMs). a BMMs were treated with miRNA-146b-5p-inhibitor for 6 h and the expression was tested by RT-PCR. b Cell counting kit-8 detection of BMMs with or without inhibitors. c RNA expression levels of CTR/TRAP/CTSK in BMMs. d TRAP staining of osteoclasts. e Representative scanning electron microscopy images of the bone resorption pits. d Western blot analysis of the phosphatase and tensin homolog (PTEN)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway and its phosphorylation activation.