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. 2023 Sep 21;4(9):1345–1361. doi: 10.1038/s43018-023-00630-y

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — A Single-dose of 3 mg/kg (top panel), 10 mg/kg (middle panel) or 50 mg/kg (bottom panel) vepafestinib was administered orally to adult male Han Wistar rats at time = 0 min. Following equilibration, samples were collected at the indicated time points and vepafestinib concentrations were then determined by HPLC with tandem mass spectrometry (MS/MS) using D₈-vepafestinib as the internal standard as described in Supplementary Methods. Data from panel c is also displayed in Fig. 8b and is included here for comparison with the other dosages used. There were 12 animals in each dosage group, and prefrontal cortex, CSF and plasma samples were obtained from 4 animals within each dosage group. The x-axis is broken to accommodate all the time points in the space. No data was eliminated between the breaks.

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